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According to its votaries, the hand of the crucified Jesus is believed to possess occult virtues. When worn as an amulet it is said to be an all-round good-luck charm. Prayers are said in conjunction with its presence on one's person. One prayer associated with this particular amulet is as follows:

"I carry a likeness of your pierced hand as a fervent symbol of your infinite kindness. Thou who has known such suffering, reach out your hand with a blessing. Thy pierced hand inspires this humble prayer that I may call on Thee to grant me peace and happiness. Amen."

Generally, charms in the form of hands, and in any pose--whether made of metal, stone, or inscribed--were often carried to ward off the "Evil Eye," or the ietattura as it is called in Southern Italy, or ain al-hasad, the "Eye of Envy," by the Arabs. The ancient Sumerians referred to it as IG-HUL, "Eye Evil." The Evil Eye is an ancient belief and not without any metaphysical substantiation. From the metaphysical point of view, eyes radiates energy and the quality of this force is tainted by the will and character of its emanator. Like all forces, the power flowing from the eyes may bless or curse others. There are many examples of amulets with a single eye on the palm of the hand. It is believed that this attracts the Evil Eye in accord with the Law of Attraction and absorbs its malevolent influences.

In order to counteract the malignant rays emanating from the eyes of negative individuals, the Hamsa Hand, or the Hand of Fatima charm was invented by the Arabs to re-direct these individuals' willful attention and malefic glances. Fatima was the daughter of the Prophet Muhammed and Khadijah. She was said to be a very virtuous woman, and it is believed that the charms representing her embody all of her solid virtues and would protect and bring good fortune to its bearer. The fingers of the Hand of Fatima symbolically represent the five pillars of Islam: 1) observance of the Ramadhan fast; 2) pilgrimage to Mecca; 3) alms-giving; 4) observance of the daily prayers; 5) profession of faith. The right hand is used to symbolize the Hand of Fatima, for it is the hand of honor, in contradistinction to the left, which is the "unclean hand." In most Eastern cultures it is considered rude and inappropriate to give things with the left hand.